Running title: Prognostic significance of CD103 TIL in ovarian carcinoma
نویسندگان
چکیده
1 Tumor-infiltrating lymphocytes expressing the tissue resident memory marker 1 CD103 are associated with increased survival in high-grade serous ovarian cancer. 2 3 John R. Webb, Katy Milne, Peter Watson, Ronald J. deLeeuw 4 and Brad H. Nelson d 5 6 7 8 9 Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, 10 Canada, Department of Biochemistry and Microbiology, University of Victoria, 11 Victoria, British Columbia, Canada, Department of Pathology and Laboratory Medicine, 12 University of British Columbia, Vancouver, British Columbia, Canada, and Department 13 of Medical Genetics, University of British Columbia, Vancouver, British Columbia, 14 Canada. 15 16 17 18 19 * Address correspondence to Dr. John R. Webb, Trev and Joyce Deeley Research Centre, 20 British Columbia Cancer Agency, Victoria, BC, Canada, V8R 6V5. (Tel) 250-519-5706, 21 (FAX) 250-519-2040, (email) [email protected] 22 23 24 25 26 27 The authors declare that they have no conflict of interest to disclose. 28 29 30
منابع مشابه
Running title: Co-expression of PD-1 and CD103 by CD8 TIL in ovarian cancer 1 PD-1 and CD103 are widely co-expressed on prognostically favorable intraepithelial CD8 T cells in human ovarian cancer
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PD-1 and CD103 Are Widely Coexpressed on Prognostically Favorable Intraepithelial CD8 T Cells in Human Ovarian Cancer.
αE(CD103)β7 is a TGFβ-regulated integrin that mediates retention of lymphocytes in peripheral tissues by binding to E-cadherin expressed on epithelial cells. We recently reported that αE(CD103)β7 specifically demarcates intraepithelial CD8(+) tumor-infiltrating lymphocytes (CD8 TIL) in ovarian cancer and that CD103(+) TIL have a surface profile consistent with an active effector phenotype (HLA-...
متن کاملCD103 and Intratumoral Immune Response in Breast Cancer.
PURPOSE CD103 is expressed in several immune cell types but in the context of the intratumoral immune response may be most important as a marker of antigen-activated CD8 T cells. METHODS We have examined the prognostic significance of CD103 TILs in breast cancer by IHC in a cohort of 424 breast cancer patients. RESULTS CD103 TILs were present in all subtypes but were more abundant in ER-neg...
متن کاملCD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy
CD103+ tumor-infiltrating lymphocytes (TIL) have been linked to specific epithelial infiltration and a prolonged survival in high-grade serous epithelial ovarian cancer (HGSC). However, whether these cells are induced as part of an ongoing anti-HGSC immune response or represent non-specifically expanded resident or mucosal lymphocytes remains largely unknown. In this study, we first confirmed t...
متن کاملThe prognostic value of tumor-infiltrating T lymphocytes in ovarian cancer
The prognostic value of tumor-infiltrating lymphocytes (TILs) in ovarian cancer is still in controversial. This study is aimed to assess the impact of different TIL subsets on the progression free survival (PFS)/disease free survival (DSS) and overall survival (OS)/disease specific survival (DSS) in ovarian cancer. A comprehensive literature search in PubMed, ISI Web of Science, and Medline was...
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